Substituted 1,3,5‐Triaryl‐1,3,5‐triazines in the Synthesis of Cyclic Azadi‐ and Triperoxides Catalyzed by Sm(NO3)3· 6H2O

Substituted 1,3,5‐Triaryl‐1,3,5‐triazines in the Synthesis of Cyclic Azadi‐ and Triperoxides Catalyzed by Sm(NO3)3· 6H2O Научная публикация

Журнал

ChemistrySelect
ISSN: 2365-6549

Вых. Данные

Год: 2025, Том: 10, Номер: 18, Номер статьи : e202501181, Страниц : DOI: 10.1002/slct.202501181

Авторы

Makhmudiyarova Nataliya N. ¹ , Ishmukhametova Irina R. ¹ , Dzhemileva Lilya U. ² , D'yakonov Vladimir A. ² , Dzhemilev Usein M. ²

Организации

1	Institute of Petrochemistry and Catalysis Ufa Federal Research Center Russian Academy of Sciences 141 Prospekt Oktyabrya Ufa 450075 Russian Federation
2	N. D. Zelinsky Institute of Organic Chemistry 47 Leninsky prospekt Moscow 119991 Russian Federation

This study addresses the reactivity of cyclic azaperoxide derivatives containing an appropriate nucleophilic function under the action of 1,3,5-triaryl-1,3,5-triazinanes with elimination of leaving groups. Criteria for predicting the chemoselectivity of the reaction and the structure of products are formulated. The ring transformation reaction of 10-aryl-7,8,12,13-tetraoxa-10-azaspiro[5.7]tridecanes and 16-aryl-6,7,13,14,18,19-hexaoxa-16-azadispiro[4.2.48.75]nonadecanes with 1,3,5-triaryl-1,3,5-triazinanes catalyzed by lanthanide compounds, giving the corresponding N-aryl-substituted azadi- and triperoxides in high yields, is studied. The developed method can be used to synthesize a broad range of functionalized cyclic peroxides using simple reaction conditions. The cytotoxic activity of eleven-membered azatriperoxides against Jurkat, K562, U937, and A549 cancer cells is evaluated for the first time.

Makhmudiyarova N.N. , Ishmukhametova I.R. , Dzhemileva L.U. , D'yakonov V.A. , Dzhemilev U.M.
Substituted 1,3,5‐Triaryl‐1,3,5‐triazines in the Synthesis of Cyclic Azadi‐ and Triperoxides Catalyzed by Sm(NO3)3· 6H2O
ChemistrySelect. 2025. V.10. N18. e202501181 . DOI: 10.1002/slct.202501181 WOS Scopus OpenAlex

Web of science:	WOS:001484389500001
Scopus:	2-s2.0-105004743967
OpenAlex:	W4410233377

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