Facile Synthesis of Furo[3,2- b ]Chromen-3-Ylacetic Acids via Multicomponent Reaction of 3-Hydroxy-4 H -Chromen-4-Ones, Arylglyoxals, and Meldrum’s Acid

Facile Synthesis of Furo[3,2- b ]Chromen-3-Ylacetic Acids via Multicomponent Reaction of 3-Hydroxy-4 H -Chromen-4-Ones, Arylglyoxals, and Meldrum’s Acid Full article

Journal

Polycyclic Aromatic Compounds
ISSN: 1563-5333 , E-ISSN: 1026-7743

Output data

Year: 2024, Volume: 44, Number: 7, Pages: 4885-4894 Pages count : 10 DOI: 10.1080/10406638.2023.2258255

Authors

Tsyganov Dmitry V. ¹ , Lichitsky Boris V. ¹ , Melekhina Valeriya G. ¹ , Komogortsev Andrey N. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

For the first time, novel method for the preparation of previously undescribed substituted 2-arylfuro[3,2-b]chromen-3-ylacetic acids was developed. The considered approach includes multicomponent reaction of various arylglyoxals, 3-hydroxy-4H-chromen-4-ones, and Meldrum’s acid. The studied condensation is a telescoped process consisting of primary base-catalyzed interaction of starting compounds in acetonitrile and conclusive cyclization to target furo[3,2-b]chromen-3-ylacetic acids under acidic conditions. The readily available starting materials, convenient experimental procedure and simple isolation of the final products are advantages of presented method.

Tsyganov D.V. , Lichitsky B.V. , Melekhina V.G. , Komogortsev A.N.
Facile Synthesis of Furo[3,2- b ]Chromen-3-Ylacetic Acids via Multicomponent Reaction of 3-Hydroxy-4 H -Chromen-4-Ones, Arylglyoxals, and Meldrum’s Acid
Polycyclic Aromatic Compounds. 2024. V.44. N7. P.4885-4894. DOI: 10.1080/10406638.2023.2258255 WOS OpenAlex

Web of science:	WOS:001070463200001
OpenAlex:	W4386859244

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