A co-crystal of heterobicyclic isomers as a product of the cyclocondensation reaction of 3,4-diaminofurazan with diethyl-2-oxosuccinate

A co-crystal of heterobicyclic isomers as a product of the cyclocondensation reaction of 3,4-diaminofurazan with diethyl-2-oxosuccinate Full article

Journal

CrystEngComm
ISSN: 1466-8033

Output data

Year: 2023, Volume: 25, Number: 38, Pages: 5413-5419 Pages count : 7 DOI: 10.1039/d3ce00769c

Authors

Romanenko Galina V. ¹ , Fokin Sergey V. ¹ , Tolstikov Svyatoslav E. ^1,2 , Letyagin Gleb A. ¹ , Ovcharenko Victor I. ^1,2 , Strizhenko Kirill V. ² , Sheremetev Aleksei B. ²

Affiliations

1	International Tomography Center, Russian Academy of Sciences, 630090 Novosibirsk, Russian Federation
2	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation

Using single crystal XRD, it was proved that the cyclocondensation of 3,4-diaminofurazan with diethyl-2-oxosuccinate gives two products belonging to different heterocyclic systems, being structural isomers – derivatives of furazano[3,4-b]pyrazin-6-one (2) and furazano[3,4-b][1,4]diazepin-7-one (6). The simultaneous formation of compounds 2 and 6 in this reaction provokes also the generation of a third solid product, an unusual co-crystal (2)0.40(6)0.60. This is a rare example of co-crystallization of two isomers, the molecules of which occupy the same position in the crystal structure, despite the differences of the heterocyclic systems.

Romanenko G.V. , Fokin S.V. , Tolstikov S.E. , Letyagin G.A. , Ovcharenko V.I. , Strizhenko K.V. , Sheremetev A.B.
A co-crystal of heterobicyclic isomers as a product of the cyclocondensation reaction of 3,4-diaminofurazan with diethyl-2-oxosuccinate
CrystEngComm. 2023. V.25. N38. P.5413-5419. DOI: 10.1039/d3ce00769c WOS Scopus OpenAlex

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