Synthesis and Immunogenicity of Pseudo-Oligosaccharides Structurally Related to Repeating Units of Capsular Phosphoglycans of Human Pathogens

Synthesis and Immunogenicity of Pseudo-Oligosaccharides Structurally Related to Repeating Units of Capsular Phosphoglycans of Human Pathogens Full article

Journal

Molecules
ISSN: 1420-3049

Output data

Year: 2025, Volume: 30, Number: 15, Article number : 3068, Pages count : DOI: 10.3390/molecules30153068

Authors

Khatuntseva Elena A. ¹ , Kamneva Anastasia A. ¹ , Yashunsky Dmitry V. ¹ , Nifantiev Nikolay E. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect 47, Moscow 119991, Russia

This review focuses on the synthesis of spacer-armed phosphooligosaccharides structurally related to the capsular phosphoglycans of pathogenic bacteria, including the Haemophilus influenzae serotypes a, b, c, and f, Neisseria meningitidis serogroups a and x, the Streptococcus pneumoniae serotypes 6a, 6b, 6c, 6f, 19a, and 19f, and the Campylobacter jejuni serotype HS:53, strain RM1221, in which the phosphodiester linkage is a structural component of a phosphoglycan backbone. Also, in this review, we summarize the current knowledge on the preparation and immunogenicity of neoglycoconjugates based on synthetic phosphooligosaccharides. The discussed data helps evaluate the prospects for the development of conjugate vaccines on the basis of synthetic phosphooligosaccharide antigens.

Khatuntseva E.A. , Kamneva A.A. , Yashunsky D.V. , Nifantiev N.E.
Synthesis and Immunogenicity of Pseudo-Oligosaccharides Structurally Related to Repeating Units of Capsular Phosphoglycans of Human Pathogens
Molecules. 2025. V.30. N15. 3068 . DOI: 10.3390/molecules30153068 WOS Scopus OpenAlex

≡ Web of science:	WOS:001549456700001
≡ Scopus:	2-s2.0-105013391710
≡ OpenAlex:	W4412587146