Green multicomponent efficient approach to (aryl)di(hetaryl)methanes bearing barbituric and hydroxypyridone moieties

Green multicomponent efficient approach to (aryl)di(hetaryl)methanes bearing barbituric and hydroxypyridone moieties Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2025, Volume: 35, Number: 5, Pages: 515-517 Pages count : 3 DOI: 10.71267/mencom.7766

Authors

Elinson Michail Nikolaevich ¹ , Ryzhkova Yuliya Evgenievna ¹ , Kalashnikova Varvara Mikhailovna ¹ , Egorov Mikhail Petrovich ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation

The new multicomponent Knoevenagel–Michael reaction between benzaldehydes and two different CH-acids, N,N'-dimethylbarbituric acid and 4-hydroxy-6-methylpyridin-2(1H)-one, proceeds in refluxing ethanol in the presence of TsOH and affords the (aryl)di(hetaryl)methane products, namely, 5-[(aryl)(2-oxo-1,2-dihydropyridin-3-yl)methyl]pyrimidine-2,4(1H,3H)-diones, in 73–94% yields. The products contain two N-heterocyclic pharmacophore moieties and seem promising for biomedical applications.

Elinson M.N. , Ryzhkova Y.E. , Kalashnikova V.M. , Egorov M.P.
Green multicomponent efficient approach to (aryl)di(hetaryl)methanes bearing barbituric and hydroxypyridone moieties
Mendeleev Communications. 2025. V.35. N5. P.515-517. DOI: 10.71267/mencom.7766 WOS Scopus OpenAlex

≡ Web of science:	WOS:001544036400004
≡ Scopus:	2-s2.0-105011676803
≡ OpenAlex:	W4413065087