Green multicomponent approach to novel 5-[(1H-pyrazol-4-yl)phenylethyl]pyrimidine-2,4(1H,3H)-diones

Green multicomponent approach to novel 5-[(1H-pyrazol-4-yl)phenylethyl]pyrimidine-2,4(1H,3H)-diones Full article

Journal

Monatshefte Fur Chemie
ISSN: 1434-4475 , E-ISSN: 0026-9247

Output data

Year: 2025, Volume: 156, Number: 8-9, Pages: 867-873 Pages count : 7 DOI: 10.1007/s00706-025-03349-x

Authors

Elinson Michail N. ¹ , Ryzhkova Yuliya E. ¹ , Kalashnikova Varvara M. ¹ , Fakhrutdinov Artem N. ¹ , Egorov Mikhail P. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

The new type of catalytic one-pot Knoevenagel-Michael reaction was found: the direct chemical one-pot transformation of phenylglyoxal, barbituric acids, and pyrazoline-5-ones in the presence of a catalytic amount of p-TsOH and in alcohols with the formation of 6-hydroxy-5-[1-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-2-oxo-2-phenylethyl]pyrimidine-2,4(1H,3H)-diones has been found. This one-pot process is a very efficient and convenient way to substituted 6-hydroxy-5-[1-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-2-oxo-2-phenylethyl]pyrimidine-2,4(1H,3H)-diones—useful compounds for different biomedical applications—using reasonable and non-expensive starting materials. Mild and facile conditions of this catalytic multicomponent process lead to excellent substance yields together with a simple non-chromatographic isolation procedure.

Elinson M.N. , Ryzhkova Y.E. , Kalashnikova V.M. , Fakhrutdinov A.N. , Egorov M.P.
Green multicomponent approach to novel 5-[(1H-pyrazol-4-yl)phenylethyl]pyrimidine-2,4(1H,3H)-diones
Monatshefte Fur Chemie. 2025. V.156. N8-9. P.867-873. DOI: 10.1007/s00706-025-03349-x WOS Scopus OpenAlex

≡ Web of science:	WOS:001541842500001
≡ Scopus:	2-s2.0-105012408333
≡ OpenAlex:	W4412862473