Structure and gene cluster of the capsular polysaccharide of Acinetobacter baumannii K104

Structure and gene cluster of the capsular polysaccharide of Acinetobacter baumannii K104 Научная публикация

Журнал

Carbohydrate Research
ISSN: 1873-426X , E-ISSN: 0008-6215

Вых. Данные

Год: 2026, Том: 559, Номер статьи : 109745, Страниц : DOI: 10.1016/j.carres.2025.109745

Авторы

Shpirt Anna M. ¹ , Serpokrylov Zakhar V. ¹ , Perepelov Andrei V. ¹ , Dmitrenok Andrei S. ¹ , Shneider Mikhail M. ² , Popova Anastasiya V. ³ , Toukach Philip V. ¹ , Knirel Yuriy A. ¹

Организации

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
2	M. M. Shemyakin & Y. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
3	State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow Region, Russia

Structure of the Acinetobacter baumannii MAR20-4513 (K104) capsular polysaccharide (CPS) was established using Smith degradation, 1H and 13C NMR spectroscopy, including two-dimensional homonuclear 1Н,1Н COSY, TOCSY, ROESY and heteronuclear 1Н,13C HSQC and HMBC experiments, and modeling. The K104 CPS is composed of a branched pentasaccharide K unit containing two d-Glcp residues, and one residue each of d-GalpNAc, d-GlcpNAc and d-Galp. The following structure of the pentasaccharide repeating unit of the CPS was established. Functions of genes in the K locus of A. baumannii K104 were assigned by a comparison with sequences in the available databases and found to be in agreement with the CPS structure.

Shpirt A.M. , Serpokrylov Z.V. , Perepelov A.V. , Dmitrenok A.S. , Shneider M.M. , Popova A.V. , Toukach P.V. , Knirel Y.A.
Structure and gene cluster of the capsular polysaccharide of Acinetobacter baumannii K104
Carbohydrate Research. 2026. V.559. 109745 . DOI: 10.1016/j.carres.2025.109745 OpenAlex

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