Efficient method for the synthesis of novel pyrano[2,3- f ]pyrazolo[3,4- d ][1,3]oxazepines from allomaltol containing pyrazoles

Efficient method for the synthesis of novel pyrano[2,3- f ]pyrazolo[3,4- d ][1,3]oxazepines from allomaltol containing pyrazoles Full article

Journal

Synthetic Communications
ISSN: 1532-2432 , E-ISSN: 0039-7911

Output data

Year: 2025, Volume: 55, Number: 22, Pages: 1680-1691 Pages count : 12 DOI: 10.1080/00397911.2025.2589481

Authors

Garbuzova Milena R. ¹ , Milyutin Constantine V. ¹ , Komogortsev Andrey N. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Science, Moscow, Russian Federation

In present study, we report efficient and straightforward method of the synthesis of pyrano[2,3-f]pyrazolo[3,4-d][1,3]oxazepine-4,6-dione derivatives, representing a completely new class of heterocycles. The presented approach employs readily available allomaltol-containing pyrazoles and proceeds via CDI-mediated cyclization as the key step. This strategy offers several advantages, including mild reaction conditions, operational simplicity, and facile isolation of the target heterocycles. The scope of the developed methodology was demonstrated through the synthesis of 21 products with yields reaching 80%. UV–vis absorption and fluorescence studies were carried out for the obtained compound. The structures of several target compounds were unambiguously established by X-ray analysis.

Garbuzova M.R. , Milyutin C.V. , Komogortsev A.N.
Efficient method for the synthesis of novel pyrano[2,3- f ]pyrazolo[3,4- d ][1,3]oxazepines from allomaltol containing pyrazoles
Synthetic Communications. 2025. V.55. N22. P.1680-1691. DOI: 10.1080/00397911.2025.2589481 WOS Scopus OpenAlex

Web of science:	WOS:001617589800001
Scopus:	2-s2.0-105022700439
OpenAlex:	W4416327312

DB	Citing
OpenAlex	Нет цитирований
Scopus	Нет цитирований