Assembly of aldehydes and dimethylbarbituric acid into spirotricyclic furopyrimidines under the action of N-bromosuccinimide in water

Assembly of aldehydes and dimethylbarbituric acid into spirotricyclic furopyrimidines under the action of N-bromosuccinimide in water Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2026, Volume: 36, Number: 1, Pages: 58-60 Pages count : 3 DOI: 10.71267/mencom.7844

Authors

Elinson Michail Nikolaevich ¹ , Ryzhkova Yuliya Evgenievna ¹ , Egorov Mikhail Petrovich ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation

A new type of chemical one-pot tandem Knoevenagel–Michael reaction followed by the NBS-induced cyclization was discovered. The reaction of aromatic aldehydes with two molecules of N,N'-dimethylbarbituric acid in the presence of NBS in water at ambient temperature affords spirotricyclic furopyrimidine scaffold, namely, 1,5-dihydro-2H,2'H-spiro[furo[2,3-d]pyrimidine-6,5'-pyrimidine]-2,2',4,4',6'-(1'H,3H,3'H)-pentones, in 90–98% yields.

Elinson M.N. , Ryzhkova Y.E. , Egorov M.P.
Assembly of aldehydes and dimethylbarbituric acid into spirotricyclic furopyrimidines under the action of N-bromosuccinimide in water
Mendeleev Communications. 2026. V.36. N1. P.58-60. DOI: 10.71267/mencom.7844 WOS OpenAlex

Web of science:	WOS:001629991500017
OpenAlex:	W4416804194

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