4,7-Functionalization of Tetradentate Phenanthroline Ligands via Nucleophilic Substitution of Fluorine

4,7-Functionalization of Tetradentate Phenanthroline Ligands via Nucleophilic Substitution of Fluorine Full article

Journal

Journal of Organic Chemistry
ISSN: 1520-6904 , E-ISSN: 0022-3263

Output data

Year: 2026, Volume: 91, Number: 1, Pages: 302-315 Pages count : 14 DOI: 10.1021/acs.joc.5c02395

Authors

Zonov Roman V. ¹ , Avagyan Nane A. ¹ , Lemport Pavel S. ¹ , Khrustalev Victor N. ^2,3 , Roznyatovsky Vitaly A. ¹ , Ustynyuk Yuri A. ¹ , Nenajdenko Valentine G. ¹

Affiliations

1	Department of Chemistry, Lomonosov Moscow State University, Leninskie gory 1 bld. 3, Moscow 119991, Russia
2	Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklay Str. 6, Moscow 117198, Russia
3	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow 119991, Russia

Funding (1)

N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences

An effective pathway for the functionalization of 1,10-phenanthroline-2,9-dicarboxamides (DAPhen) to positions 4 and 7 of the heterocyclic backbone by nucleophilic aromatic substitution was developed. The developed approach makes it possible to introduce various functional groups of almost any nature into positions 4 and 7 of the phenanthroline nucleus. The introduction of reactive functional groups, such as the azide group, has allowed for further functionalization. Thus, a set of novel symmetrically or unsymmetrically 4,7-disubstituted DAPhen ligands was prepared.

Zonov R.V. , Avagyan N.A. , Lemport P.S. , Khrustalev V.N. , Roznyatovsky V.A. , Ustynyuk Y.A. , Nenajdenko V.G.
4,7-Functionalization of Tetradentate Phenanthroline Ligands via Nucleophilic Substitution of Fluorine
Journal of Organic Chemistry. 2026. V.91. N1. P.302-315. DOI: 10.1021/acs.joc.5c02395 WOS Scopus OpenAlex

Submitted:	Sep 23, 2025
Published online:	Jan 9, 2026

Web of science:	WOS:001644816300001
Scopus:	2-s2.0-105027184359
OpenAlex:	W7116663377

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OpenAlex	Нет цитирований
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