Hydrazine Derivatives as C-Centered Radical Precursors for C-C Bond Formation Reactions Review
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Molecules
ISSN: 1420-3049 |
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| Output data | Year: 2026, Volume: 31, Number: 1, Article number : 67, Pages count : DOI: 10.3390/molecules31010067 | ||
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Abstract:
Organic monosubstituted hydrazine derivatives (Ar-NHNH2, RC(O)-NHNH2, Alkyl-NHNH2) are synthetically available, atom-efficient and stable sources of C-centered radicals upon oxidation with extrusion of the energetically favorable N2 molecule. This review summarizes the synthetic application of monosubstituted hydrazine derivatives (arylhydrazines, carbazates, acylhydrazides, hydrazine carboxamides and alkylhydrazines) in free-radical C-C bond-forming reactions. The main application directions in this field are (a) alkene difunctionalization, (b) cascade cyclization initiated by the addition of hydrazine-derived C-centered radicals to acrylamides and isonitriles, and (c) CH-functionalization of (hetero)arenes via C-centered radical addition followed by oxidative dehydrogenation (re-aromatization).
Cite:
Lopat’eva E.R.
, Krylov I.B.
, Terent’ev A.O.
Hydrazine Derivatives as C-Centered Radical Precursors for C-C Bond Formation Reactions
Molecules. 2026. V.31. N1. 67 . DOI: 10.3390/molecules31010067 WOS Scopus OpenAlex
Hydrazine Derivatives as C-Centered Radical Precursors for C-C Bond Formation Reactions
Molecules. 2026. V.31. N1. 67 . DOI: 10.3390/molecules31010067 WOS Scopus OpenAlex
Dates:
| Submitted: | Nov 26, 2025 |
| Published online: | Dec 24, 2025 |
Identifiers:
| ≡ Web of science: | WOS:001657554800001 |
| ≡ Scopus: | 2-s2.0-105027151356 |
| ≡ OpenAlex: | W7117112793 |