Consistent supramolecular motifs and different local symmetries in the structures of 2-amino-5-(4-fluorophenyl)-1,3-thiazole-4-carbaldehyde and 2-amino-5-(4-chlorophenyl)-1,3-thiazole-4-carbaldehyde

Consistent supramolecular motifs and different local symmetries in the structures of 2-amino-5-(4-fluorophenyl)-1,3-thiazole-4-carbaldehyde and 2-amino-5-(4-chlorophenyl)-1,3-thiazole-4-carbaldehyde Full article

Journal

Acta Crystallographica Section E: Crystallographic Communications
ISSN: 2056-9890

Output data

Year: 2026, Volume: 82, Number: 1, Pages: 14-18 Pages count : 5 DOI: 10.1107/s2056989025010667

Authors

Guseinov Firudin I. ^1,2 , Afanaseva Ksenia A. ^1,2 , Gaidar Sergey M. ³ , Pikina Anna M. ³ , Akkurt Mehmet ⁴ , Aliyeva Fargana S. ⁵ , Hasanov Khudayar I. ⁶ , Belay Alebel N. ⁷

Affiliations

1	Kosygin State University of Russia, 117997 Moscow, Russian Federation
2	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
3	Russian State Agrarian University-Moscow Timiryazev Agricultural Academy, 127550 Moscow, Russian Federation
4	Department of Physics, Faculty of Sciences, Erciyes University, 38039 Kayseri, Türkiye
5	Excellence Center, Baku State University, Z. Xalilov Str. 23, Az 1148 Baku, Azerbaijan
6	Azerbaijan Medical University, Scientific Research Centre (SRC), Kasumzade St. 14. AZ 1022, Baku, Azerbaijan
7	Department of Chemistry, Bahir Dar University, PO Box 79, Bahir Dar, Ethiopia

Funding (1)

The first title compound, C10H7FN2OS, crystallizes in space group P1 with two independent molecules in the asymmetric unit, which form a dimer with an R22(8) motif through pairwise N—H⋯N hydrogen bonds. In the crystal of (I), N—H⋯O hydrogen bonds bind the dimers into zigzag ribbons running along the [100] direction, generating R44(14) motifs. The second title compound, C10H7ClN2OS (space group I2/a), contains one molecule in the asymmetric unit, which forms a dimer with an R22(8) motif via inversion symmetry. In the extended structure, the molecules form zigzag ribbons in the [100] direction by N—H⋯N and N—H⋯O hydrogen bonds, resulting in consecutive R41(8)R21(5)R22(8)R21(5)R41(8) motifs. The Hirshfeld surface analyses of the compounds (I) and (II) indicates that the most important factors influencing the crystal packing are H⋯H interactions [21.1% for molecule A of (I), 20.3% for molecule B of (I) and 21.0% for (II)].

Guseinov F.I. , Afanaseva K.A. , Gaidar S.M. , Pikina A.M. , Akkurt M. , Aliyeva F.S. , Hasanov K.I. , Belay A.N.
Consistent supramolecular motifs and different local symmetries in the structures of 2-amino-5-(4-fluorophenyl)-1,3-thiazole-4-carbaldehyde and 2-amino-5-(4-chlorophenyl)-1,3-thiazole-4-carbaldehyde
Acta Crystallographica Section E: Crystallographic Communications. 2026. V.82. N1. P.14-18. DOI: 10.1107/s2056989025010667 WOS Scopus OpenAlex

Web of science:	WOS:001662259100004
Scopus:	2-s2.0-105026867029
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