New Synthesis of Aryl-Substituted 3,3,4-Trihydroxy-2,3,4,10-tetrahydrobenzo[4,5]imidazo[2,1-b][1,3]thiazinium Salts

New Synthesis of Aryl-Substituted 3,3,4-Trihydroxy-2,3,4,10-tetrahydrobenzo[4,5]imidazo[2,1-b][1,3]thiazinium Salts Full article

Journal

Russian Journal of Organic Chemistry
ISSN: 1608-3393 , E-ISSN: 1070-4280

Output data

Year: 2025, Volume: 61, Number: 9, Pages: 1582-1591 Pages count : 10 DOI: 10.1134/s1070428025602468

Authors

Guseinov F.I. ^1,2 , Kustov L.M. ² , Afanasyeva K.A. ^1,2 , Shuvalova E.V. ² , Kobrakov K.I. ^1,2 , Sebyakin Yu.L. ³ , Stepanov A.V. ² , Samigullina A.I. ²

Affiliations

1	Kosygin State University of Russia, 119071, Moscow, Russia
2	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia
3	MIREA—Russian Technology University (Lomonosov Institute of Fine Chemical Technology), 119571, Moscow, Russia

A preparative method has been developed for the synthesis of previously unknown 3,3,4-trihydroxybenzimidazo[2,1-b][1,3]thiazinium salts in up to 93% yield by the microwave-assisted reaction of chloro oxiranes and chloro ketones containing an acetal moiety with 1-ethyl-1H-benzimidazole-2-thiol in 95% ethanol. The synthesized compounds are of interest for medicinal chemistry.

Guseinov F.I. , Kustov L.M. , Afanasyeva K.A. , Shuvalova E.V. , Kobrakov K.I. , Sebyakin Y.L. , Stepanov A.V. , Samigullina A.I.
New Synthesis of Aryl-Substituted 3,3,4-Trihydroxy-2,3,4,10-tetrahydrobenzo[4,5]imidazo[2,1-b][1,3]thiazinium Salts
Russian Journal of Organic Chemistry. 2025. V.61. N9. P.1582-1591. DOI: 10.1134/s1070428025602468 WOS Scopus OpenAlex

Web of science:	WOS:001606916400013
Scopus:	2-s2.0-105020645403
OpenAlex:	W4415726354

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