Synthesis of a new hybrid compound based on camptothecin and lithocholic acid and study of its antitumor properties

Synthesis of a new hybrid compound based on camptothecin and lithocholic acid and study of its antitumor properties Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2025, Volume: 74, Number: 8, Pages: 2592-2597 Pages count : 6 DOI: 10.1007/s11172-025-4741-0

Authors

Chobanov N.M. ¹ , Dzhemileva L.U. ¹ , Dzhemilev U.M. ¹ , D’yakonov V.A. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

A hybrid compound containing fragments of lithocholic acid and the antitumor alkaloid camptothecin linked to each other through an anhydride and an ester group with a succinic acid fragment was synthesized for the first time. The resulting compound was found to be an effective inducer of apoptosis and capable of causing cell cycle arrest.

Chobanov N.M. , Dzhemileva L.U. , Dzhemilev U.M. , D’yakonov V.A.
Synthesis of a new hybrid compound based on camptothecin and lithocholic acid and study of its antitumor properties
Russian Chemical Bulletin. 2025. V.74. N8. P.2592-2597. DOI: 10.1007/s11172-025-4741-0 WOS Scopus OpenAlex

Web of science:	WOS:001574171100011
Scopus:	2-s2.0-105015488308
OpenAlex:	W4414142532

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