Synthesis of hybrid compounds based on 5Z,9Z-dienoic acids and polycyclic amines and study of their cytotoxic activity

Synthesis of hybrid compounds based on 5Z,9Z-dienoic acids and polycyclic amines and study of their cytotoxic activity Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2025, Volume: 74, Number: 7, Pages: 2207-2213 Pages count : 7 DOI: 10.1007/s11172-025-4706-3

Authors

Makarov A.A. ¹ , Dzhemileva L.U. ² , Makarova E.Kh. ¹ , Dzhemilev U.M. ² , D’yakonov V.A. ²

Affiliations

1	Institute of Petrochemistry and Catalysis, Ufa Federal Research Center of the Russian Academy of Sciences, 141 prosp. Oktyabrya, 450075, Ufa, Russian Federation
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

New hybrid compounds were synthesized by the reaction of effective inhibitors of human topoisomerase I, natural (5Z,9Z)-eicosa-5,9-dienoic acid and synthetic (5Z,9Z)-phenylundeca-5,9-dienoic acid, with polycyclic amines. The obtained hybrid compounds were found to have pronounced cytotoxic activity against five studied cell lines (Jurkat, U937, K562, HEK293, fibroblasts), with the lead compound showing selective activity against Jurkat and K562 cells; its activity was found to be comparable with that of comparison drugs, camptothecin and etoposide.

Makarov A.A. , Dzhemileva L.U. , Makarova E.K. , Dzhemilev U.M. , D’yakonov V.A.
Synthesis of hybrid compounds based on 5Z,9Z-dienoic acids and polycyclic amines and study of their cytotoxic activity
Russian Chemical Bulletin. 2025. V.74. N7. P.2207-2213. DOI: 10.1007/s11172-025-4706-3 WOS Scopus OpenAlex

Web of science:	WOS:001554001100005
Scopus:	2-s2.0-105013390990
OpenAlex:	W4413462014

DB	Citing
OpenAlex	Нет цитирований
Scopus	Нет цитирований