Synthesis of new 4-(5-R-1-phenyl-1H-1,2,4-triazol-3-yl)benzamides

Synthesis of new 4-(5-R-1-phenyl-1H-1,2,4-triazol-3-yl)benzamides Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2025, Volume: 74, Number: 5, Pages: 1428-1437 Pages count : 10 DOI: 10.1007/s11172-025-4639-x

Authors

Firsova A.A. ^1,2 , Chernyshov V.V. ² , Esaulkova I.L. ³ , Salakhov T.L. ² , Saliev A.Yu. ² , Ivanov R.A. ² , Zarubaev V.V. ³ , Vatsadze S.Z. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
2	“Sirius” University of Science and Technology, 1 Olimpiyskiy prosp., 354340, Sochi, Federal territory “Sirius”, Russian Federation
3	St. Petersburg Pasteur Institute of Epidemiology and Microbiology, 14 ul. Mira, 197101, St. Petersburg, Russian Federation

New trisubstituted 1,2,4-triazoles were synthesized which contain two aromatic substituents at positions 1 and 3 of the heterocycle, as well as a varied one at position 5 which includes sp3-hybridized carbon atoms. The obtained compounds, differing, in particular, in lipophilicity, number of heteroatoms, size/presence of a ring, were studied for antiviral activity against the influenza virus A/Puerto Rico/8/34 (H1N1), as well as for antifungal activity against fungi of the genus C. albicans ATCC 10231 and antibacterial activity against laboratory strain of E. coli MG1655.

Firsova A.A. , Chernyshov V.V. , Esaulkova I.L. , Salakhov T.L. , Saliev A.Y. , Ivanov R.A. , Zarubaev V.V. , Vatsadze S.Z.
Synthesis of new 4-(5-R-1-phenyl-1H-1,2,4-triazol-3-yl)benzamides
Russian Chemical Bulletin. 2025. V.74. N5. P.1428-1437. DOI: 10.1007/s11172-025-4639-x WOS Scopus OpenAlex

Web of science:	WOS:001508341700020
Scopus:	2-s2.0-105008452757
OpenAlex:	W4411310769

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