Synthesis of (1,2,4-Triazinyl)furazans | Sciact - научная деятельность

Synthesis of (1,2,4-Triazinyl)furazans Научная публикация

Журнал

Russian Journal of Organic Chemistry
ISSN: 1608-3393 , E-ISSN: 1070-4280

Вых. Данные

Год: 2025, Том: 61, Номер: 7, Страницы: 1311-1318 Страниц : 8 DOI: 10.1134/s1070428025602298

Авторы

Larin A.A. ^1,2 , Shaferov A.V. ² , Ananyev I.V. ³ , Fershtat L.L. ²

Организации

1	Litvinenko Institute of Physical Organic and Coal Chemistry, 283048, Donetsk, Russia
2	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia
3	Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia

4-Methyl- and 4-amino-1,2,5-oxadiazole-3-carbohydrazonamides reacted with glyoxal to give the corresponding dimeric products, N′,N″-(ethane-1,2-diylidene)bis(4-R-1,2,5-oxadiazole-3-carbohydrazonamides) (R = Me, NH2), whereas the reaction of the same substrates with other 1,2-dicarbonyl compounds, such as benzil and ninhydrin afforded target 3-(4-R-1,2,5-oxadiazol-3-yl)-1,2,4-triazine derivatives. The product structure was confirmed by IR and NMR spectra and X-ray analysis. The synthesized compounds are promising as scaffolds for the design of pharmacologically active compounds with different kinds of activity.

Larin A.A. , Shaferov A.V. , Ananyev I.V. , Fershtat L.L.
Synthesis of (1,2,4-Triazinyl)furazans
Russian Journal of Organic Chemistry. 2025. V.61. N7. P.1311-1318. DOI: 10.1134/s1070428025602298 WOS Scopus OpenAlex

Web of science:	WOS:001552065700002
Scopus:	2-s2.0-105013502465
OpenAlex:	W4413285881

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