Metal-free organic synthesis in liquefied gases: achievements and prospects Review
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Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285 |
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| Output data | Year: 2025, Volume: 74, Number: 7, Pages: 1914-1928 Pages count : 15 DOI: 10.1007/s11172-025-4678-3 | ||
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Abstract:
The potential of carbon dioxide and 1,1,1,2-tetrafluoroethane in their liquid and supercritical states as environmentally friendly (green) solvents for metal-free liquid-phase chemical transformations has been substantiated. This review summarizes data on N-, O-, and C-nitration carried out in these media. Particular attention is given to the application of liquid (liq-CO2) and supercritical carbon dioxide (sc-CO2) in condensation of carbonyl compounds with amines, including the one-pot tandem transformations of the resulting imines. The oxidative functionalization of cycloalkanes induced by near-UV light in the presence of nitrogen dioxide under sc-CO2 conditions is discussed. The effectiveness of sc-CO2 as a solvent in photooxidation of alcohols and sulfides with molecular oxygen in the presence of such metal-free photocatalysts as 2-fluoroanthraquinone and graphitic carbon nitride is demonstrated. Additionally, recent advances in asymmetric aldol reactions, conjugate additions, and cascade reactions catalyzed by chiral amines in liq-CO2 and sc-CO2 media are reviewed.
Cite:
Kuchurov I.V.
, Zharkov M.N.
, Zlotin S.G.
Metal-free organic synthesis in liquefied gases: achievements and prospects
Russian Chemical Bulletin. 2025. V.74. N7. P.1914-1928. DOI: 10.1007/s11172-025-4678-3 WOS Scopus OpenAlex
Metal-free organic synthesis in liquefied gases: achievements and prospects
Russian Chemical Bulletin. 2025. V.74. N7. P.1914-1928. DOI: 10.1007/s11172-025-4678-3 WOS Scopus OpenAlex
Identifiers:
| Web of science: | WOS:001554001100004 |
| Scopus: | 2-s2.0-105013396168 |
| OpenAlex: | W4413458629 |