Synthesis and antibacterial activity of new bis-quaternary ammonium compounds based on 2,5-diformylfuran and pentaerythritol

Synthesis and antibacterial activity of new bis-quaternary ammonium compounds based on 2,5-diformylfuran and pentaerythritol Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2025, Volume: 74, Number: 4, Pages: 1099-1105 Pages count : 7 DOI: 10.1007/s11172-025-4603-9

Authors

Saverina E.A. ^1,2 , Frolov N.A. ^1,2 , Tyutin A.A. ^3,1 , Lantsova E.A. ² , Detusheva E.V. ^1,4 , Son E. ⁴ , Vereshchagin A.N. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
2	Tula State University, 92 prosp. Lenina, 300012, Tula, Russian Federation
3	D. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya pl., 125047, Moscow, Russian Federation
4	State Research Center for Applied Microbiology and Biotechnology, 24 territory “Quartal A”, 142279, Obolensk, Moscow Region, Russian Federation

Successive condensation of pentaerythritol with 4-formylpyridine and 2,5-diformylfuran yielded a hybrid platform containing two pyridine and two pentaerythritol fragments and one furan fragment. N-Alkylation of this platform with alkyl iodides led to new bis-quaternary ammonium compounds. An assessment of the bacteriostatic and bactericidal potential of the obtained compounds against reference and clinical strains of ESKAPE pathogens, as well as yeast-like fungus Candida albicans, showed their ability to inhibit the growth and destroy mature biofilms of gram-positive and gram-negative bacteria and fungi. When comparing the activity of the synthesized compounds with known antiseptics (octenidine dihydrochloride and cetylpyridinium chloride), it was found that they are effective against various strains of S. aureus, E. coli, K. pneumoniae, P. aeruginosa and C. albicans.

Saverina E.A. , Frolov N.A. , Tyutin A.A. , Lantsova E.A. , Detusheva E.V. , Son E. , Vereshchagin A.N.
Synthesis and antibacterial activity of new bis-quaternary ammonium compounds based on 2,5-diformylfuran and pentaerythritol
Russian Chemical Bulletin. 2025. V.74. N4. P.1099-1105. DOI: 10.1007/s11172-025-4603-9 WOS Scopus OpenAlex

Web of science:	WOS:001489981900012
Scopus:	2-s2.0-105005272593
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