Synthesis of 2-Carboxamide-Substituted Benzimidazoles via S8-Promoted Multicomponent Reaction in Aqueous Media

Synthesis of 2-Carboxamide-Substituted Benzimidazoles via S8-Promoted Multicomponent Reaction in Aqueous Media Full article

Journal

Tetrahedron
ISSN: 0040-4020 , E-ISSN: 1464-5416

Output data

Year: 2026, Volume: 193, Article number : 135130, Pages count : DOI: 10.1016/j.tet.2025.135130

Authors

Birukova Valentina ¹ , Chursin Anatoly Y. ¹ , Zavarzin Igor V. ¹ , Volkova Yulia A. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

A novel approach to the synthesis of 2-carboxamide-substituted benzimidazoles from a wide range of 1,2-diamines and 2-functionalized acetamides was developed via elemental sulfur promoted cascade reaction. This procedure provides an efficient and facile route to benzimidazoles from readily available substrates under mild reaction conditions. The protocol is distinguished by efficiency in water and good tolerance to functional groups.

Birukova V. , Chursin A.Y. , Zavarzin I.V. , Volkova Y.A.
Synthesis of 2-Carboxamide-Substituted Benzimidazoles via S8-Promoted Multicomponent Reaction in Aqueous Media
Tetrahedron. 2026. V.193. 135130 . DOI: 10.1016/j.tet.2025.135130 WOS Scopus OpenAlex

Submitted:	Nov 17, 2025
Published online:	Jan 16, 2026

≡ Web of science:	WOS:001672586700001
≡ Scopus:	2-s2.0-105027476945
≡ OpenAlex:	W7118131738