Synthesis and X-ray structure of potent anticancer 4-(4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)isoxazole

Synthesis and X-ray structure of potent anticancer 4-(4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)isoxazole Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2024, Volume: 34, Number: 4, Pages: 511-513 Pages count : 3 DOI: 10.1016/j.mencom.2024.06.013

Authors

Kislyi Victor P. ¹ , Maksimenko Anna S. ¹ , Samigullina Aida I. ¹ , Semenova Marina N. ² , Semenov Victor V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
2	N. K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russian Federation

The three-step synthesis of potent anticancer 4-(4-methoxy- phenyl)-3-(3,4,5-trimethoxyphenyl)isoxazole starting from 1,2,3-trimethoxy-5-(nitromethyl)benzene and anisaldehyde was developed. In phenotypic sea urchin embryo assay, this compound exhibited antimitotic antitubulin activity comparable to that of the natural cytostatic combretastatin A4 (CA4). The title isoxazole inhibited in vitro growth of A549 human lung cancer cells and PC-3 human prostate cancer cells with IC50 values of 8 and 6 nm, respectively, exceeding the effect of CA4.

Kislyi V.P. , Maksimenko A.S. , Samigullina A.I. , Semenova M.N. , Semenov V.V.
Synthesis and X-ray structure of potent anticancer 4-(4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)isoxazole
Mendeleev Communications. 2024. V.34. N4. P.511-513. DOI: 10.1016/j.mencom.2024.06.013 WOS Scopus OpenAlex

Web of science:	WOS:001293476200001
Scopus:	2-s2.0-85200805479
OpenAlex:	W4401451402

DB	Citing
OpenAlex	4
Scopus	3
Web of science	2