The synthesis and study of antimicrobial activity of 5-oxo-1-(thiazol-2-yl)pyrrolidine-3-carboxylic acids

The synthesis and study of antimicrobial activity of 5-oxo-1-(thiazol-2-yl)pyrrolidine-3-carboxylic acids Научная публикация

Журнал

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Вых. Данные

Год: 2024, Том: 60, Номер: 7-8, Страницы: 365-370 Страниц : 6 DOI: 10.1007/s10593-024-03348-6

Авторы

Serkov Sergei A. ¹ , Kostikova Natalya N. ¹ , Sigay Natalya V. ¹ , Tyurin Anton P. ² , Kolotyrkina Natalya G. ¹ , Gazieva Galina A. ¹

Организации

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow, 119991, Russia
2	Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow, 117997, Russia

A series of novel 5-oxo-1-(thiazol-2-yl)pyrrolidine-3-carboxylic acids were synthesized via condensation of 2-aminothiazole derivatives and itaconic acid by heating without a solvent. An ester and amide of 1-(benzothiazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid were obtained. 1-(6-Nitrobenzo[d]thiazol-2-yl)- and 1-{5-[(4-nitrophenyl)sulfonyl]thiazol-2-yl}-5-oxopyrrolidine-3-carboxylic acids exhibited bacteriostatic activity against the Gram-positive bacterium Bacillus subtilis ATCC 6633 strain.

Serkov S.A. , Kostikova N.N. , Sigay N.V. , Tyurin A.P. , Kolotyrkina N.G. , Gazieva G.A.
The synthesis and study of antimicrobial activity of 5-oxo-1-(thiazol-2-yl)pyrrolidine-3-carboxylic acids
Chemistry of Heterocyclic Compounds. 2024. V.60. N7-8. P.365-370. DOI: 10.1007/s10593-024-03348-6 WOS Scopus OpenAlex

≡ Web of science:	WOS:001326687700004
≡ Scopus:	2-s2.0-85205381786
≡ OpenAlex:	W4403042269