Synthesis of Novel Azides and Triazoles on the Basis of 1н-Pyrazole-3(5)-Carboxylic Acids

Synthesis of Novel Azides and Triazoles on the Basis of 1н-Pyrazole-3(5)-Carboxylic Acids Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Output data

Year: 2020, Volume: 56, Number: 2, Pages: 180-191 Pages count : 12 DOI: 10.1007/s10593-020-02643-2

Authors

Dalinger Aleksander I. ¹ , Medved’ko Alexey V. ¹ , Balalaeva Alexandra I. ¹ , Vatsadze Irina А. ² , Dalinger Igor L. ² , Vatsadze Sergey Z. ¹

Affiliations

1	Lomonosov Moscow State University 1, Build. 3, Leninskie Gory, Moscow, Russia
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

The goal of this work was to obtain novel ligands basedis on 1H-pyrazole-3(5)-carboxylic acids containing the triazole moiety at positions 3(6) or 4. Another goal was to study the possibility of joining pyrazole carboxylic acid fragments with various framework structures to create polychelated ligands that can be used in medicinal chemistry and metal complex catalysis. Methods have been developed for the synthesis of previously unknown N-unsubstituted 5- and 4-azido-1H-pyrazole-3-carboxylic acids from the corresponding available amino derivatives in high yields. For the first time, the joining of bispidines to azoles was carried out using the copper-catalyzed [3+2] cycloaddition reaction.

Dalinger A.I. , Medved’ko A.V. , Balalaeva A.I. , Vatsadze I.А. , Dalinger I.L. , Vatsadze S.Z.
Synthesis of Novel Azides and Triazoles on the Basis of 1н-Pyrazole-3(5)-Carboxylic Acids
Chemistry of Heterocyclic Compounds. 2020. V.56. N2. P.180-191. DOI: 10.1007/s10593-020-02643-2 WOS Scopus OpenAlex

≡ Web of science:	WOS:000527962300008
≡ Scopus:	2-s2.0-85081974487
≡ OpenAlex:	W3011422148