Sustainable electrochemical synthesis of aliphatic nitro-NNO-azoxy compounds employing ammonium dinitramide and their in vitro evaluation as potential nitric oxide donors and fungicides

Sustainable electrochemical synthesis of aliphatic nitro-NNO-azoxy compounds employing ammonium dinitramide and their in vitro evaluation as potential nitric oxide donors and fungicides Full article

Journal

Beilstein Journal of Organic Chemistry
ISSN: 2195-951X , E-ISSN: 1860-5397

Output data

Year: 2025, Volume: 21, Pages: 2739-2754 Pages count : 16 DOI: 10.3762/bjoc.21.211

Authors

Budnikov Alexander S ¹ , Leonov Nikita E ¹ , Klenov Michael S ¹ , Kulikov Andrey A ¹ , Krylov Igor B ¹ , Kudryashev Timofey A ¹ , Churakov Aleksandr M ¹ , Terent’ev Alexander O ¹ , Tartakovsky Vladimir A ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation

An atom- and step-economical electrochemical method for the synthesis of aliphatic nitro-NNO-azoxy compounds from the corresponding nitroso compounds was developed employing ammonium dinitramide, a prospective green oxidant for aerospace propulsion applications, as both electrolyte and source of a =NNO2 group. The developed method is green, practical, and scalable due to constant current electrolysis in an undivided cell at high current densities. Synthesized products demonstrated pronounced NO-donor activity and fungicidal activity against phytopathogenic fungi.

Budnikov A.S. , Leonov N.E. , Klenov M.S. , Kulikov A.A. , Krylov I.B. , Kudryashev T.A. , Churakov A.M. , Terent’ev A.O. , Tartakovsky V.A.
Sustainable electrochemical synthesis of aliphatic nitro-NNO-azoxy compounds employing ammonium dinitramide and their in vitro evaluation as potential nitric oxide donors and fungicides
Beilstein Journal of Organic Chemistry. 2025. V.21. P.2739-2754. DOI: 10.3762/bjoc.21.211 WOS OpenAlex

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