New Structural Modifications of Cotarnine Alkaloid Derivatives: Cotarnone and Dihydrocotarnine

New Structural Modifications of Cotarnine Alkaloid Derivatives: Cotarnone and Dihydrocotarnine Full article

Journal

Russian Journal of General Chemistry
ISSN: 1070-3632 , E-ISSN: 1608-3350

Output data

Year: 2020, Volume: 90, Number: 2, Pages: 238-243 Pages count : 6 DOI: 10.1134/s1070363220020127

Authors

Kartsev V.G. ¹ , Zubenko A.A. ² , Divaeva L.N. ³ , Morkovnik A.S. ³ , Baryshnikova T.K. ⁴ , Shirinian V.Z. ⁴

Affiliations

1	InterBioScreen Ltd, 142432, Chernogolovka, Russia
2	North Caucasian Zonal Veterinary Research Institute, Federal Rostov Agrarian Scientific Center, 346406, Novocherkassk, Russia
3	Institute of Physical and Organic Chemistry of Southern Federal University, 344090, Rostov-on-Don, Russia
4	N.D. Zelinsky Institute of Organic Chemistry of Russian Academy of Sciences, 119991, Moscow, Russia

Simplest derivatives of the cotarnine alkaloid, like cotarnone and 1,2-dihydrocotarnine, undergo electrophilic Einhorn acylamidomethylation (with 60–95% yield) and sulfochlorination with chlorosulfonic acid at position 5. At the same time cotarnone and its derivatives undergo additional O-protodemethylation. Using these and some other reactions, we synthesized a number of previously unknown derivatives of two substrates with 5-chloroacetamidomethyl, 5-arylaminomethyl, 5-aminomethyl and 5-sulfamide groups.

Kartsev V.G. , Zubenko A.A. , Divaeva L.N. , Morkovnik A.S. , Baryshnikova T.K. , Shirinian V.Z.
New Structural Modifications of Cotarnine Alkaloid Derivatives: Cotarnone and Dihydrocotarnine
Russian Journal of General Chemistry. 2020. V.90. N2. P.238-243. DOI: 10.1134/s1070363220020127 WOS Scopus OpenAlex

Web of science:	WOS:000522647800012
Scopus:	2-s2.0-85083091180
OpenAlex:	W3014881260

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OpenAlex	3
Scopus	3
Web of science	3