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Cytotoxicity of multi-purpose protic ionic liquids towards human dermal fibroblasts Full article

Journal Journal of Molecular Liquids
ISSN: 0167-7322 , E-ISSN: 1873-3166
Output data Year: 2025, Volume: 433, Article number : 127948, Pages count : DOI: 10.1016/j.molliq.2025.127948
Authors Ratmanova Nina K. 1 , Posvyatenko Alexandra V. 2 , Levina Irina I. 3 , Seitkalieva Marina M. 2 , Khrustalev Victor N. 2,1 , Ermolaev Valery P. 4 , Ivanova Olga A. 5 , Trushkov Igor V. 2 , Egorova Ksenia S. 2 , Andreev Ivan A. 1
Affiliations
1 Science Faculty, Patrice Lumumba Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya st. 6, 117198 Moscow, Russian Federation
2 N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky pr. 47, 119991 Moscow, Russian Federation
3 N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygina st. 4, 119334 Moscow, Russian Federation
4 Higher Chemical College of the Russian Academy of Sciences, D. I. Mendeleev Russian University of Chemical Technology, Miusskaya Ploshchad’ 9, 125047 Moscow, Russian Federation
5 Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie gory 1-3, 119991 Moscow, Russian Federation

Abstract: Thiocyanate-containing protic ionic liquids (PILs) have previously proven to be useful reagents for conducting diverse chemical transformations. A fundamentally new concept of multi-purpose application of these PILs opens up new opportunities in organic synthesis. However, their safety has not been thoroughly assessed so far. In this work, we carried out a systematic investigation of cytotoxicity of a series of synthetically valuable thiocyanate-containing PILs towards normal human dermal fibroblasts (DF-1) and human embryonic kidney cells (HEK293T). In particular, the impact of anion on the cytotoxicity was studied for dual-purpose triethylamine-based PILs. The study of cellular damage markers yielded additional insights into the mechanisms of PILs’ cytotoxicity.
Cite: Ratmanova N.K. , Posvyatenko A.V. , Levina I.I. , Seitkalieva M.M. , Khrustalev V.N. , Ermolaev V.P. , Ivanova O.A. , Trushkov I.V. , Egorova K.S. , Andreev I.A.
Cytotoxicity of multi-purpose protic ionic liquids towards human dermal fibroblasts
Journal of Molecular Liquids. 2025. V.433. 127948 . DOI: 10.1016/j.molliq.2025.127948 Scopus OpenAlex
Identifiers:
Scopus: 2-s2.0-105007754574
OpenAlex: W4411163299
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