Synthesis and nucleophilic dearomatization of novel [1,2,4]triazolo[1,5-a]pyrimidines Научная публикация
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Tetrahedron
ISSN: 0040-4020 , E-ISSN: 1464-5416 |
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| Вых. Данные | Год: 2026, Том: 193, Номер статьи : 135153, Страниц : DOI: 10.1016/j.tet.2026.135153 | ||
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Реферат:
A number of novel 2-R-6-nitro[1,2,4]triazolo[1,5-a]pyrimidines were synthesized. Their reactions with neutral C-nucleophiles (1,3-dicarbonyl compounds, indoles, polyphenols) proceeded under mild conditions (room temperature, no base or catalyst) giving rise to stable 1,4-adducts to pyrimidine ring. On the basis of 7-amino-6-nitro[1,2,4]triazolo[1,5-a]pyrimidines, a method was developed for the preparation of the previously unknown heterocyclic systems, namely [1,2,4]triazolo[1,5-a]pyrimidines fused with 1,2,5-oxa-, thia- and selenadiazole rings. These new heterocycles were found to undergo facile dearomatization under the action of 1,3-dicarbonyl compounds and π-excessive (het)arenes to give 1,2-adducts to pyrimidine ring. The possibility of oxidative rearomatization of the obtained adducts under the action of DDQ was demonstrated.
Библиографическая ссылка:
Kolyadina S.
, Kruchinin A.
, Minyaev M.
, Bastrakov M.
, Starosotnikov A.
Synthesis and nucleophilic dearomatization of novel [1,2,4]triazolo[1,5-a]pyrimidines
Tetrahedron. 2026. V.193. 135153 . DOI: 10.1016/j.tet.2026.135153 WOS Scopus OpenAlex
Synthesis and nucleophilic dearomatization of novel [1,2,4]triazolo[1,5-a]pyrimidines
Tetrahedron. 2026. V.193. 135153 . DOI: 10.1016/j.tet.2026.135153 WOS Scopus OpenAlex
Даты:
| Поступила в редакцию: | 28 нояб. 2025 г. |
| Опубликована online: | 20 янв. 2026 г. |
Идентификаторы БД:
| Web of science: | WOS:001674962300001 |
| Scopus: | 2-s2.0-105027561499 |
| OpenAlex: | W7124581805 |
Цитирование в БД:
| БД | Цитирований |
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| OpenAlex | Нет цитирований |
| Scopus | Нет цитирований |