Synthesis and antioxidant activity of apiol-derived 3-arylpropanamines

Synthesis and antioxidant activity of apiol-derived 3-arylpropanamines Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2026, Volume: 36, Number: 2, Pages: 167-170 Pages count : 4 DOI: 10.71267/mencom.7859

Authors

Blinnikov A.N. ¹ , Malibiche M.М. ¹ , Adaeva O.I. ¹ , Krylov S.S. ¹ , Shevchenko O.G. ² , Demchuk D.V. ¹ , Semenova M.N. ¹ , Semenov V.V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
2	Institute of Biology, Komi Science Center, Ural Branch of the Russian Academy of Sciences, 167982 Syktyvkar, Russian Federation

3-(2,5-Dimethoxy-3,4-methylenedioxyphenyl)propan-1-amines were synthesized in three steps in 62–68% overall yields using apiol extracted from parsley seeds as a starting material. The compounds obtained being structurally similar to neurotropic amphetamines demonstrated in vitro radical scavenging activity in mouse brain lipids and red blood cells together with the lack of embryotoxicity in the sea urchin embryo model. The presence of pyrrolidine or morpholine moieties was beneficial for the antioxidant activity.

Blinnikov A.N. , Malibiche M.М. , Adaeva O.I. , Krylov S.S. , Shevchenko O.G. , Demchuk D.V. , Semenova M.N. , Semenov V.V.
Synthesis and antioxidant activity of apiol-derived 3-arylpropanamines
Mendeleev Communications. 2026. V.36. N2. P.167-170. DOI: 10.71267/mencom.7859 Scopus OpenAlex

Submitted:	Jun 26, 2025
Published online:	Feb 3, 2026

Scopus:	2-s2.0-105030472680
OpenAlex:	W7127423772

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