Base-promoted deacylation of 2-acetyl-2,5-dihydrothiophenes and their oxygen-mediated hydroxylation

Base-promoted deacylation of 2-acetyl-2,5-dihydrothiophenes and their oxygen-mediated hydroxylation Научная публикация

Журнал

Beilstein Journal of Organic Chemistry
ISSN: 2195-951X , E-ISSN: 1860-5397

Вых. Данные

Год: 2026, Том: 22, Страницы: 192-204 Страниц : 13 DOI: 10.3762/bjoc.22.13

Авторы

Ilkin Vladimir G ¹ , Likhacheva Margarita ¹ , Trushkov Igor V ² , Beryozkina Tetyana V ¹ , Berseneva Vera S ¹ , Abaev Vladimir T ^3,4 , Dehaen Wim ⁵ , Bakulev Vasiliy A ¹

Организации

1	TOS Department, Ural Federal University, 19 Mira str., Yekaterinburg 620002, Russia
2	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky ave., Moscow 119991, Russia
3	North Caucasus Federal University, 1 Pushkin st., Stavropol 355009, Russia
4	North-Ossetian State University, 46 Vatutina st., Vladikavkaz 362025, Russia
5	Sustainable Chemistry for Metals and Molecules, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven B-3001, Belgium

Solvent-dependent transformations of polysubstituted 2-acetyl-2,5-dihydrothiophenes to the corresponding 2-hydroxy- or deacetylated derivatives are described. The treatment of a methanolic solution of the dihydrothiophene substrates with sodium methoxide afforded the deacylated products. Conversely, the treatment with sodium ethoxide in an oxygen saturated ethanolic solution produced 2-hydroxy substituted 2,5-dihydrothiophenes.

Ilkin V.G. , Likhacheva M. , Trushkov I.V. , Beryozkina T.V. , Berseneva V.S. , Abaev V.T. , Dehaen W. , Bakulev V.A.
Base-promoted deacylation of 2-acetyl-2,5-dihydrothiophenes and their oxygen-mediated hydroxylation
Beilstein Journal of Organic Chemistry. 2026. V.22. P.192-204. DOI: 10.3762/bjoc.22.13 OpenAlex

Поступила в редакцию:	28 авг. 2025 г.
Опубликована online:	28 янв. 2026 г.

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