Abstract: The new type of multicomponent tandem Knoevenagel–Michael reaction with further cyclization was found: the transformation of arylaldehydes, N,N´-dialkylbarbituric acids and 4-hydroxycoumarin by the action of morpholine, and then N-bromosuccinimide in ethanol without any other additives at ambient temperature led to selective formation of the medicinally relevant unsymmetrical spirobarbituric 2,3-dihydro-4H-furo[2,3-c]chromen-4-ones with three pharmacology active heterocyclic rings in 85%–98% yields. This new multicomponent reaction is a simple selective and efficient way to spiro[furo[3,2-c]chromene-2,5′-pyrimidines], which are promising compounds for the different biomedical applications, among them anticonvulsants, anti-AIDS agents, and anti-inflammatory remedies. This synthetic multicomponent procedure does not require heating, long reaction times, or complex equipment. It is easy to carry out, and the procedure for isolating the final compounds is very simple. This new multicomponent method is applicable for large-scale processes with modern environmental requirements. All these advantages make this method valuable for the synthesis of new potential biologically active compounds.

Cite: Elinson M.N. , Ryzhkova Y.E. , Kalashnikova V.M. , Fakhrutdinov A.N. , Egorov M.P.
Multicomponent Selective Assembling Aldehydes, N , N′ ‐Dialkylbarbituric Acids, and 4‐Hydroxycoumarin Into Medicinally Relevant Spirobarbituric 2,3‐Dihydro‐ 4 H ‐Furo[2,3‐ c ]Chromen‐4‐One Scaffold
Journal of Heterocyclic Chemistry. 2026. DOI: 10.1002/jhet.70176 Scopus OpenAlex

Dates:

Submitted:	Dec 9, 2025
Published print:	Feb 18, 2026

Identifiers:

Scopus:	2-s2.0-105030483464
OpenAlex:	W7130420857

Citing:

DB	Citing
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