Photocatalytic Sulfonyl Peroxidation of Alkenes via Deamination of N-Sulfonyl Ketimines

Photocatalytic Sulfonyl Peroxidation of Alkenes via Deamination of N-Sulfonyl Ketimines Full article

Journal

Organic Letters
ISSN: 1523-7060 , E-ISSN: 1523-7052

Output data

Year: 2024, Volume: 26, Number: 9, Pages: 1920-1925 Pages count : 6 DOI: 10.1021/acs.orglett.4c00241

Authors

Feng Yuting ¹ , Chen Shujun ¹ , Lv Leiyang ¹ , Yaremenko Ivan A. ² , Terent’ev Alexander O. ² , Li Zhiping ¹

Affiliations

1	Key Laboratory of Advanced Light Conversion Materials and Biophotonics, Department of Chemistry, Renmin University of China, Beijing 100872, China
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prosp., 119991 Moscow, Russia

A photocatalytic three-component sulfonyl peroxidation of alkenes with N-sulfonyl ketimines and tert-butyl hydroperoxide is reported. The reaction takes place via the photoinduced EnT process, which allows the efficient synthesis of a variety of β-peroxyl sulfones under mild reaction conditions in the absence of a transition metal catalyst. The downstream derivatizations of the peroxides were also performed. Furthermore, the utility of this protocol was manifested by the synthesis of 11β-HSD1 inhibitor and the antiprostate cancer drug bicalutamide.

Feng Y. , Chen S. , Lv L. , Yaremenko I.A. , Terent’ev A.O. , Li Z.
Photocatalytic Sulfonyl Peroxidation of Alkenes via Deamination of N-Sulfonyl Ketimines
Organic Letters. 2024. V.26. N9. P.1920-1925. DOI: 10.1021/acs.orglett.4c00241 WOS Scopus OpenAlex

Web of science:	WOS:001172841600001
Scopus:	2-s2.0-85186190073
OpenAlex:	W4392023998

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