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A novel thiadiazole-steroid hybrid as a CYP19A1 inhibitor: Synthesis, molecular interaction analysis and assessment of steroid receptor signaling Научная публикация

Журнал The Journal of Steroid Biochemistry and Molecular Biology
ISSN: 1879-1220 , E-ISSN: 0960-0760
Вых. Данные Год: 2026, Том: 260, Номер статьи : 106974, Страниц : DOI: 10.1016/j.jsbmb.2026.106974
Авторы Volkova Yulia A. 1 , Dzichenka Yaraslau U. 2 , Sorokin Danila V. 3 , Malakhova Victoria R. 1 , Uvarov Denis Y. 1 , Chursin Anatoly Y. 1 , Sidunets Yurii A. 1 , Chebotkova Darya V. 2 , Usanov Sergey A. 2 , Bogdanov Fedor B. 3 , Khamidullina Alvina I. 1,4,5 , Salnikova Diana I. 1,3,6 , Scherbakov Alexander M. 3,6 , Zavarzin Igor V. 1
Организации
1 N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., Moscow 119991, Russia. Electronic address: yavolkova@ioc.ac.ru
2 Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, 5/2 ulitsa Akademika Kuprevicha, Minsk 220084, Belarus
3 Department of Experimental Tumor Biology, N.N. Blokhin National Medical Research Center of Oncology, 24 Kashirskoe shosse, Moscow 115522, Russia
4 Laboratory of Molecular Oncobiology, Institute of Gene Biology, Russian Academy of Sciences, 34/5 ulitsa Vavilova, Moscow 119334, Russia
5 Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences, 71 prosp. Octyabrya, Ufa 450054, Russia
6 Gause Institute of New Antibiotics, 11 Bol’shaya Pirogovskaya ulitsa, Moscow 119021, Russia
Библиографическая ссылка: Volkova Y.A. , Dzichenka Y.U. , Sorokin D.V. , Malakhova V.R. , Uvarov D.Y. , Chursin A.Y. , Sidunets Y.A. , Chebotkova D.V. , Usanov S.A. , Bogdanov F.B. , Khamidullina A.I. , Salnikova D.I. , Scherbakov A.M. , Zavarzin I.V.
A novel thiadiazole-steroid hybrid as a CYP19A1 inhibitor: Synthesis, molecular interaction analysis and assessment of steroid receptor signaling
The Journal of Steroid Biochemistry and Molecular Biology. 2026. V.260. 106974 . DOI: 10.1016/j.jsbmb.2026.106974 WOS Scopus OpenAlex
Даты:
Поступила в редакцию: 10 окт. 2025 г.
Принята к публикации: 25 февр. 2026 г.
Опубликована online: 26 февр. 2026 г.
Идентификаторы БД:
≡ Web of science: WOS:001711240500001
≡ Scopus: 2-s2.0-105031860399
≡ OpenAlex: W7131619281
Альметрики: