Direct synthesis and cytotoxic activity of new macrodiolides with 2,5-disubstituted tetrahydrofuran moieties

Direct synthesis and cytotoxic activity of new macrodiolides with 2,5-disubstituted tetrahydrofuran moieties Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2026, DOI: 10.71267/mencom.7923

Authors

Islamov Ilgiz Ilshatovich ¹ , Makarov Aleksey Aleksandrovich ¹ , Gajsin Ilgam Vaisovich ¹ , Dzhemileva Lilya Useinovna ² , Dzhemilev Usein Memetovich ² , D'yakonov Vladimir Anatol'evich ²

Affiliations

1	Institute of Petrochemistry and Catalysis, Ufa Federal Research Centre of the Russian Academy of Sciences, 450075 Ufa, Russian Federation
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation

A novel strategy for synthesizing new polyfunctional macrodiolides based on the oxidative cyclization of (1Z,5Z)-diene bonds to form 2,5-disubstituted tetrahydrofurans has been developed. The unsaturated macrodiolide was obtained using an original catalytic homo-cyclomagnesiation of O-containing 1,2-dienes (the Dzhemilev reaction). The macrocyclic compounds demonstrated cytotoxic activity in tests on Jurkat, A549, and HEK293 cell lines.

Islamov I.I. , Makarov A.A. , Gajsin I.V. , Dzhemileva L.U. , Dzhemilev U.M. , D'yakonov V.A.
Direct synthesis and cytotoxic activity of new macrodiolides with 2,5-disubstituted tetrahydrofuran moieties
Mendeleev Communications. 2026. DOI: 10.71267/mencom.7923 OpenAlex

Submitted:	Sep 23, 2025
Accepted:	Nov 17, 2025

≡ OpenAlex:

W7135237460