Abstract: Designing versatile transition metal based approaches to deliberately selective functionalization of the abundant and poorly reactive aliphatic C–H bonds in organic molecules, listed among the “Holy grails” of synthetic chemistry 30 years ago (R. Bergman, 1995), is now gradually becoming a common laboratory practice. Undoubtedly, not all of the proposed catalysts and methods will approach the stage of practical application; most likely, this can happen only with those that demonstrate sufficient versatility, in combination with high performance and selectivity. On the other hand, of practical interest may be approaches exhibiting unique, otherwise unattainable catalytic reactivities and/or selectivities. Among the plethora of catalytic systems for C–H oxyfunctionalizations, those relying on light platinum group elements (LPGEs) Ru, Rh, Pd are promising candidates to join the second category. This contribution surveys the progress and state-of-the-art of Ru-, Rh-, Pd-catalyzed C(sp3)–H into C–O bond transformations, with focus on the coordination chemistry aspects and synthetic perspective of these reactions, as well as essential mechanistic details.

Cite: Lubov D.P. , Bryliakov K.P.
Selective C(sp3)–H Oxyfunctionalizations in the Presence of Ru, Rh, and Pd Based Catalysts
Coordination Chemistry Reviews. 2026. V.562. 217891 . DOI: 10.1016/j.ccr.2026.217891 WOS Scopus OpenAlex

Dates:

Submitted:	Jun 2, 2025
Published online:	Apr 11, 2026

Identifiers:

≡ Web of science:	WOS:001745487400001
≡ Scopus:	2-s2.0-105035316006
≡ OpenAlex:	W7153510473

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