Study of the Complexation of Thiowurtzine with Cyclodextrins

Study of the Complexation of Thiowurtzine with Cyclodextrins Full article

Journal

Russian Journal of General Chemistry
ISSN: 1070-3632 , E-ISSN: 1608-3350

Output data

Year: 2026, Volume: 96, Number: 4, Article number : 76, Pages count : DOI: 10.1134/s1070363225607574

Authors

Lobova Natalia A. ^1,2 , Aleksandrova Anastasiya V. ² , Medyantsev Evgeny S. ^1,2 , Aleхandrov Alexander A. ^3,4 , Avakyan Vitaly G. ² , Titov Sergey V. ² , Vatsadze Sergey Z. ⁵

Affiliations

1	Moscow Center for Advanced Studies, 123592, Moscow, Russia
2	National Research Center Kurchatov Institute, 123182, Moscow, Russia
3	Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, 119991, Moscow, Russia
4	Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991, Moscow, Russia
5	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia

The complexation ability of one of the new promising analgesics, thiowurtzine (TW), with a number of cyclodextrin (CD) host molecules was studied using electron and 1H NMR spectroscopy in methanol and confirmed by quantum-chemical and molecular dynamics calculations. Spectrophotometric and fluorescence titration methods determined the 1 : 1 stoichiometry and stability of the resulting complexes with γ-cyclodextrin derivatives (for TW@HP-γ-CD log K1:1 = 3.0).

Lobova N.A. , Aleksandrova A.V. , Medyantsev E.S. , Aleхandrov A.A. , Avakyan V.G. , Titov S.V. , Vatsadze S.Z.
Study of the Complexation of Thiowurtzine with Cyclodextrins
Russian Journal of General Chemistry. 2026. V.96. N4. 76 . DOI: 10.1134/s1070363225607574 WOS Scopus OpenAlex

Submitted:	Nov 9, 2025
Published online:	Mar 19, 2026

≡ Web of science:	WOS:001718807800004
≡ Scopus:	2-s2.0-105033479609
≡ OpenAlex:	W7138955371