gem ‐Difluorinated Phosphonium Salts as Sources of Difluoroalkyl Radicals

gem ‐Difluorinated Phosphonium Salts as Sources of Difluoroalkyl Radicals Review

Journal

Chemical Record
ISSN: 1527-8999 , E-ISSN: 1528-0691

Output data

Year: 2026, Article number : e70150, Pages count : DOI: 10.1002/tcr.70150

Authors

Trifonov Alexey L. ¹ , Dilman Alexander D. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry Moscow Russian Federation

The advent of photoredox catalysis established difluorinated phosphonium salts as the valuable type of difluoroalkyl radical sources that stand out from the row of fluoroalkylative reagents. The synthetic application of this class of compounds varies from simple, yet robust and universal photoinduced difluoromethylation to assembling rather complex difluorinated frameworks. This review summarizes the radical difluoroalkylation reactions, which utilize difluorinated phosphonium salts employed as reagents or intermediate compounds from the first report in 2015.

Trifonov A.L. , Dilman A.D.
gem ‐Difluorinated Phosphonium Salts as Sources of Difluoroalkyl Radicals
Chemical Record. 2026. e70150 . DOI: 10.1002/tcr.70150 WOS Scopus OpenAlex

Submitted:	Jan 22, 2026
Published print:	Apr 17, 2026

≡ Web of science:	WOS:001742919300001
≡ Scopus:	2-s2.0-105035785675
≡ OpenAlex:	W7154836983