Sustainable ruthenium-catalyzed C–H alkylation of 2-(hetero)aryl benzimidazoles with maleimides

Sustainable ruthenium-catalyzed C–H alkylation of 2-(hetero)aryl benzimidazoles with maleimides Full article

Journal

New Journal of Chemistry
ISSN: 1369-9261 , E-ISSN: 1144-0546

Output data

Year: 2026, Volume: 50, Number: 20, Pages: 8550-8554 Pages count : 5 DOI: 10.1039/d6nj00299d

Authors

Shepelenko Konstantin E. ^1,2 , Gnatiuk Irina G. ¹ , Kolotova Uliana A. ² , Minyaev Mikhayl E. ³ , Chernyshev Victor M. ^1,2

Affiliations

1	Platov South-Russian State Polytechnic University (NPI), Prosveshcheniya st., 132, 346428, Novocherkassk, Russian Federation
2	Skolkovo Institute of Science and Technology, Build. 1, 30 Bol'shoy b-r, Skolkovo Innovation Center, 121205, Moscow, Russian Federation
3	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow, 119991, Russian Federation

An efficient protocol for the ruthenium-catalyzed C–H alkylation of 2-(hetero)aryl benzimidazoles with maleimides is reported. Key features include the use of an inexpensive, bench-stable [RuCl2(p-cymene)]2 precatalyst in the green solvent 2-MeTHF under air, without stoichiometric metal additives. This work establishes the benzimidazol-2-yl group as a competent directing group and offers a practical, sustainable route to valuable heterocyclic scaffolds.

Shepelenko K.E. , Gnatiuk I.G. , Kolotova U.A. , Minyaev M.E. , Chernyshev V.M.
Sustainable ruthenium-catalyzed C–H alkylation of 2-(hetero)aryl benzimidazoles with maleimides
New Journal of Chemistry. 2026. V.50. N20. P.8550-8554. DOI: 10.1039/d6nj00299d OpenAlex

Submitted:	Jan 25, 2026
Published online:	Apr 30, 2026

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