Synthesis of novel antibiofilm kojic acid-based bis-pyridinium salts

Synthesis of novel antibiofilm kojic acid-based bis-pyridinium salts Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2026, Volume: 36, Number: 4, Pages: 395-397 Pages count : 3 DOI: 10.71267/mencom.7940

Authors

Frolov Nikita Andreevich ¹ , Seferyan Mary A ¹ , Valeev Anver B ^2,1 , Vinokurov Andrey D ¹ , Sychyov Artemiy ^1,3 , Detusheva Elena Vladimirovna ^1,4 , Vereshchagin Anatoly Nikolaevich ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
2	Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russian Federation
3	National Research University Higher School of Economics (HSE University), 101000 Moscow, Russian Federation
4	State Research Center for Applied Microbiology & Biotechnology, 142279 Obolensk, Moscow Region, Russian Federation

Six novel 1,3-disubstituted bis-pyridinium compounds containing two kojic acid fragments in the linker were synthesized via three simple steps from kojic acid, 1,4-di-bromobutane and 3-(alkylamino)pyridines. An assessment of the bacteriostatic and bactericidal potential of the obtained compounds against reference and clinical strains of ESKAPE pathogens showed their ability to inhibit the growth and to destroy mature biofilms of Gram-positive and Gram-negative bacteria.

Frolov N.A. , Seferyan M.A. , Valeev A.B. , Vinokurov A.D. , Sychyov A. , Detusheva E.V. , Vereshchagin A.N.
Synthesis of novel antibiofilm kojic acid-based bis-pyridinium salts
Mendeleev Communications. 2026. V.36. N4. P.395-397. DOI: 10.71267/mencom.7940 OpenAlex

Submitted:	Oct 14, 2025
Published online:	Jun 4, 2026

≡ OpenAlex:

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