Abstract: For the first time, the multicomponent reaction of labile 2-aminothiophenes with aldehydes and malononitrile was investigated. We have shown that the considered process leads to the formation of thieno[2,3-b]pyridine derivatives containing cyano- and amino groups. Sodium salts of 2-aminothiophene-3-carboxylic acids were utilized as straightforward precursors for the generation of unstable 2-aminothiophenes in situ. Based on the presented multicomponent condensation, the general method for the synthesis of final 6-aminothieno[2,3-b]pyridine-5-carbonitriles was designed. The elaborated procedure allowed us to obtain a large array of target products with yields up to 68%. Advantages of the developed approach are easily available starting materials, atom economy, and convenient isolation of prepared compounds without chromatographic purification. The structure of one representative of the synthesized thieno[2,3-b]pyridines was confirmed by X-ray analysis.

Cite: Komkov I.A. , Lichitsky B.V.
Synthesis of Substituted 6‐Aminothieno[2,3‐ b ]Pyridine‐5‐Carbonitriles by Multicomponent Condensation of 2‐Aminothiophenes With Aldehydes and Malononitrile
Journal of Heterocyclic Chemistry. 2026. DOI: 10.1002/jhet.70222 WOS Scopus OpenAlex

Dates:

Submitted:	Apr 15, 2026
Accepted:	Jun 25, 2026
Published print:	Jul 2, 2026

Identifiers:

≡ Web of science:	WOS:001810070400001
≡ Scopus:	2-s2.0-105043804728
≡ OpenAlex:	W7167261147

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