Ring opening in dihydrocoumarin derivatives as a convenient approach to the N-acylation of l-carnosine with arylpropanoic acids

Ring opening in dihydrocoumarin derivatives as a convenient approach to the N-acylation of l-carnosine with arylpropanoic acids Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2026, Volume: 75, Number: 4, Pages: 1246-1253 Pages count : 8 DOI: 10.1007/s11172-026-4977-3

Authors

Adaeva O.I. ¹ , Demchuk D.V. ¹ , Kulikova O.I. ² , Semenov V.V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
2	Research Center of Neurology, 5 per. Obukha, 105064, Moscow, Russian Federation

A synthetic approach to a series of N-acyl derivatives of l-carnosine was developed. It involves ring opening of six-membered lactones, particularly dihydrocoumarin derivatives. In contrast to the common acylation methods, the proposed approach does not require reagents of peptide synthesis, since dihydrocoumarin behaves as the reactive activated ester.

Adaeva O.I. , Demchuk D.V. , Kulikova O.I. , Semenov V.V.
Ring opening in dihydrocoumarin derivatives as a convenient approach to the N-acylation of l-carnosine with arylpropanoic acids
Russian Chemical Bulletin. 2026. V.75. N4. P.1246-1253. DOI: 10.1007/s11172-026-4977-3 OpenAlex

Адаева О.И. , Демчук Д.В. , Куликова О.И. , Семёнов В.В.
Раскрытие цикла в производных дигидрокумарина как удобный способ N-ацилирования L-карнозина арилпропановыми кислотами
Известия Академии наук. Серия химическая. 2026. Т.75. №4. С.1246-1253.

Submitted:	Oct 6, 2025
Published online:	Jun 29, 2026

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