Accumulation and Genotoxicity of UiO-66 Nanoparticles in Freshwater Fish Nothobranchius rachovii

Accumulation and Genotoxicity of UiO-66 Nanoparticles in Freshwater Fish Nothobranchius rachovii Full article

Journal

Journal of Xenobiotics
ISSN: 2039-4713

Output data

Year: 2026, Volume: 16, Number: 5, Article number : 175, Pages count : DOI: 10.3390/jox16050175

Authors

Abramenko Natalia ¹ , Vergun Vadim ² , Jukova Julia ¹ , Topolenko Varvara ¹ , Simanovsky Sergey ¹ , Isaeva Vera ² , Krysanov Eugene ¹ , Kustov Leonid ^3,2

Affiliations

1	A.N. Severtsov Institute of Ecology and Evolution Russian Academy of Sciences, Leninsky Prospect, 33, Moscow 119071, Russia
2	N.D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, Leninsky Prospect, 47, Moscow 119991, Russia
3	Chemistry Department, Moscow State University, Leninskie Gory 1, bldg. 3, Moscow 119991, Russia

Metal–organic frameworks (MOFs) possess remarkable physicochemical properties, making them highly attractive candidates for advanced drug delivery, catalysis, water purification, gas separation, and biomedical application. Thus, it is important to understand its toxic effect on the environment and human health prior to wide practical application. In this study, UiO-66 nanoparticles (Zr6O4(OH)4—octahedral clusters with benzene-1,4-dicarboxylate linkers) were synthesized and characterized by XRD, SEM, and TEM techniques. The genotoxicity and accumulation of UiO-66 were investigated towards freshwater fish, Nothobranchius rachovii, for the first time. To gain a better understanding of the effects of UiO-66 nanoparticles towards N. rachovii, fish were exposed to UiO-66, the linker, and zirconium salts. The genotoxic risk caused by UiO-66 was detected by analyzing the Chromosome Aberrations (CAs), frequencies of Sister Chromatid Exchanges (SCEs), mitotic index, and accumulations of Zr in tissues of fish treated with UiO-66 samples, linker, zirconium salt, and non-exposed control subjects.

Abramenko N. , Vergun V. , Jukova J. , Topolenko V. , Simanovsky S. , Isaeva V. , Krysanov E. , Kustov L.
Accumulation and Genotoxicity of UiO-66 Nanoparticles in Freshwater Fish Nothobranchius rachovii
Journal of Xenobiotics. 2026. V.16. N5. 175 . DOI: 10.3390/jox16050175 OpenAlex

Submitted:	Aug 10, 2026
Published online:	Sep 16, 2026

≡ OpenAlex:

W7213413000