A Janus Aglycone-Based Divergent Strategy for the Synthesis of the PGL-I Epitopes Ready for Conjugation Научная публикация
| Журнал |
Organic Letters
ISSN: 1523-7060 , E-ISSN: 1523-7052 |
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| Вых. Данные | Год: 2026, Том: 28, Номер: 40, Страницы: 12791–12796 Страниц : DOI: 10.1021/acs.orglett.6c03850 | ||
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Реферат:
An efficient synthesis of epitopes of PGL-I glycolipids of Mycobacterium leprae was achieved using the 4-methoxyphenyl (MP) group as dual-mode Janus aglycone. Cleavage of the MP aglycone in a disaccharide gave a hemiacetal precursor of the glycosyl donor that was used for the assembly of the trisaccharide PGL-I epitope through α-selective [2+1] rhamnosylation (96:4 α:β). Selective demethylation of the MP aglycone in di- and trisaccharides followed by alkylation of the resulting phenolic hydroxy group gave diverse spacer aglycones suitable for the synthesis of neoglycoconjugates.
Библиографическая ссылка:
Novosad B.L.
, Zinin A.I.
, Kolotyrkina N.G.
, Kononov L.O.
A Janus Aglycone-Based Divergent Strategy for the Synthesis of the PGL-I Epitopes Ready for Conjugation
Organic Letters. 2026. V.28. N40. P.12791–12796. DOI: 10.1021/acs.orglett.6c03850 WOS Scopus OpenAlex
A Janus Aglycone-Based Divergent Strategy for the Synthesis of the PGL-I Epitopes Ready for Conjugation
Organic Letters. 2026. V.28. N40. P.12791–12796. DOI: 10.1021/acs.orglett.6c03850 WOS Scopus OpenAlex
Даты:
| Поступила в редакцию: | 30 авг. 2026 г. |
| Принята к публикации: | 21 сент. 2026 г. |
| Опубликована online: | 25 сент. 2026 г. |
Идентификаторы БД:
| ≡ Web of science: | WOS:001887230200001 |
| ≡ Scopus: | 2-s2.0-105052796705 |
| ≡ OpenAlex: | W7214287867 |