Enantioselective synthesis of indan-1-one-based chromones via asymmetric organocatalysis with bifunctional tertiary amine

Enantioselective synthesis of indan-1-one-based chromones via asymmetric organocatalysis with bifunctional tertiary amine Full article

Journal

New Journal of Chemistry
ISSN: 1369-9261 , E-ISSN: 1144-0546

Output data

Year: 2026, DOI: 10.1039/d6nj03031a

Authors

Zhanabaeva Madina ¹ , Kovalevsky Ruslan ¹ , Kucherenko Alexander ¹ , Zlotin Sergei Grigorievich ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991, Moscow, Russian Federation

A new approach to asymmetric synthesis of potentially pharmacophoric hybrid molecules which contain 3- hydroxychromone and indan-1-one structural fragments from available precursors based on the use of cinchonidinederived squaramide organocatalyst has been proposed. The reaction is readily scalable, has a wide scope and allows attaining chiral molecules in up to 90% yield with 89-98% ee. The absolute (S)-configuration of chiral products was proved by the conversion to known levorotatory (S)-1-indancarboxylic acid. Further derivatization of the obtained compounds was also demonstrated.

Zhanabaeva M. , Kovalevsky R. , Kucherenko A. , Zlotin S.G.
Enantioselective synthesis of indan-1-one-based chromones via asymmetric organocatalysis with bifunctional tertiary amine
New Journal of Chemistry. 2026. DOI: 10.1039/d6nj03031a OpenAlex

Published online:

Oct 8, 2026

≡ OpenAlex:

W7220921992