Four-Year Field Evaluation of a New Thiocyanate Fungicide: Significant Reduction in Late Blight ( Phytophthora infestans ) Severity and Increased Potato Yield

Four-Year Field Evaluation of a New Thiocyanate Fungicide: Significant Reduction in Late Blight ( Phytophthora infestans ) Severity and Increased Potato Yield Full article

Journal

ACS Agricultural Science & Technology
ISSN: 2692-1952

Output data

Year: 2026, DOI: 10.1021/acsagscitech.6c00444

Authors

Kirillov Andrey S. ¹ , Bityukov Oleg V. ^2,1 , Kuznetsova Maria A. ^3,1 , Demidova Valentina N. ^3,1 , Kostyagina Vera A. ^2,1 , Vil’ Vera A. ¹ , Terent’ev Alexander O. ^2,1

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation
2	Russian Federation; D. I. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Square, 125047 Moscow, Russian Federation
3	All-Russian Research Institute for Phytopathology, B. Vyazyomy, 143050 Moscow Region, Russian Federation

Late blight, caused by Phytophthora infestans (P. infestans), is a major potato disease worldwide. Resistance of P. infestans to existing fungicides necessitates alternative solutions with other modes of action. Previously, we reported a new family of fungicides: 2-thiocyano-1,3-dicarbonyl compounds, based on an in vitro study. Here, we present results of four-year field trials (2022–2025) evaluating the efficacy of the lead compound, 3-hexyl-3-thiocyanatopentane2,4-dione, compared with fluazinam (Shirlan) for late blight control and yield improvement in the Moscow region (high P. infestans background). The experiment used a randomized block design (four replications) with the susceptible cultivar Red Scarlet. The thiocyanate fungicide consistently reduced the area under the disease progress curve by 27% (2022), 41% (2023), 66% (2024), and 72% (2025), compared with the nontreated control (NTC). Tuber yield increased by 10%, 66%, 85%, and 64%, respectively, vs NTC. Aqueous formulations of 3-hexyl-3-thiocyanatopentane-2,4-dione (119–200 g/ha) containing sodium dodecyl sulfate and sodium alginate showed the highest efficacy. These results demonstrate the potential of this new compound for effective late blight management and resistance mitigation strategies in potato production.

Kirillov A.S. , Bityukov O.V. , Kuznetsova M.A. , Demidova V.N. , Kostyagina V.A. , Vil’ V.A. , Terent’ev A.O.
Four-Year Field Evaluation of a New Thiocyanate Fungicide: Significant Reduction in Late Blight ( Phytophthora infestans ) Severity and Increased Potato Yield
ACS Agricultural Science & Technology. 2026. DOI: 10.1021/acsagscitech.6c00444

Submitted:	Apr 28, 2026
Accepted:	Aug 10, 2026
Published online:	Oct 12, 2026

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