Abstract: A general method for the synthesis of a previously unknown 3H-furo[3,2-d]pyrazolo[3,4-b]pyridine system was elaborated. The considered route is based on the annulation of the furan ring to the pyrazolo[3,4-b]pyridine framework via a multicomponent reaction with various arylglyoxals and Meldrum's acid. Employing the aforementioned protocol, a series of target 3H-furo[3,2-d] pyrazolo[3,4-b]pyridin-8-yl acetic acids was prepared in yields up to 83%. The designed approach enables the application of a wide range of readily available starting 5-hydroxypyrazolo[3,4-b]pyridines and α-ketoaldehydes with diverse substituents in the aromatic fragments. The synthetic utility of the obtained furylacetic acids was demonstrated by further conversion of the carboxyl group into an ester moiety.

Cite: Kudryavtseva T.A. , Lichitsky B.V.
A Multicomponent Approach to the Assembly of a Novel 3H-Furo[3,2-d]Pyrazolo[3,4-b]Pyridine Core
Journal of Heterocyclic Chemistry. 2026. DOI: 10.1002/jhet.70261

Dates:

Submitted:	Sep 2, 2026
Accepted:	Nov 4, 2026
Published print:	Nov 11, 2026

Identifiers: No identifiers

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