Synthesis and Study of New Anticoagulant Candidates Based on 6-Aryl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones

Synthesis and Study of New Anticoagulant Candidates Based on 6-Aryl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones Научная публикация

Журнал

Russian Journal of General Chemistry
ISSN: 1070-3632 , E-ISSN: 1608-3350

Вых. Данные

Год: 2023, Том: 93, Номер: S1, Страницы: S115-S123 Страниц : DOI: 10.1134/s1070363223140359

Авторы

Skoptsova A.A. ¹ , Novichikhina N.P. ¹ , Kosheleva E.A. ¹ , Baranin S.V. ² , Podoplelova N.A. ³ , Panteleev M.A. ³ , Shikhaliev Kh.S. ¹

Организации

1	Voronezh State University, Voronezh, Russia
2	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
3	Center for Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Moscow, Russia

The reaction of 6-aryl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones with 3-acetylcoumarins led to the formation of a new series of 1-[2-oxo-2-(2-oxo-2H-chromen-3-yl)ethylidene]-6-aryl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2(1H)-ones. Primary in vitro screening of anticoagulant activity against coagulation factors Xa and XIa was performed for all target compounds. The IC50 value was also determined for the structures that showed the highest inhibition values among synthesized molecules.

Skoptsova A.A. , Novichikhina N.P. , Kosheleva E.A. , Baranin S.V. , Podoplelova N.A. , Panteleev M.A. , Shikhaliev K.S.
Synthesis and Study of New Anticoagulant Candidates Based on 6-Aryl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones
Russian Journal of General Chemistry. 2023. V.93. NS1. P.S115-S123. DOI: 10.1134/s1070363223140359 WOS Scopus OpenAlex

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