Synthesis of the substituted 7 H -pyrano[2,3- d ]isoxazol-7-ones from allomaltol-containing oximes

Synthesis of the substituted 7 H -pyrano[2,3- d ]isoxazol-7-ones from allomaltol-containing oximes Full article

Journal

Synthetic Communications
ISSN: 1532-2432 , E-ISSN: 0039-7911

Output data

Year: 2023, Volume: 53, Number: 24, Pages: 2108-2116 Pages count : 9 DOI: 10.1080/00397911.2023.2272208

Authors

Milyutin Constantine V. ¹ , Komogortsev Andrey N. ¹ , Melekhina Valeriya G. ¹ , Lichitsky Boris V. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Science, Moscow, Russian Federation

Convenient approach for the synthesis of previously unknown 7H-pyrano[2,3-d]isoxazol-7-one core was elaborated. The presented method is based on two stage process including preparation of diketone monoximes and their subsequent intramolecular dehydration. It was shown that among various dehydrating agents the best results were achieved using system TsCl/Et3N. The advantages of the considered procedure are easily available starting compounds, simple experimental procedure and isolation of the final products, avoiding column chromatography.

Milyutin C.V. , Komogortsev A.N. , Melekhina V.G. , Lichitsky B.V.
Synthesis of the substituted 7 H -pyrano[2,3- d ]isoxazol-7-ones from allomaltol-containing oximes
Synthetic Communications. 2023. V.53. N24. P.2108-2116. DOI: 10.1080/00397911.2023.2272208 WOS Scopus OpenAlex

Web of science:	WOS:001089234800001
Scopus:	2-s2.0-85174835729
OpenAlex:	W4387959327

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Web of science	2