A New Catalytic Method for the Synthesis of Cyclic Azaperoxides with High Cytotoxic Activity

A New Catalytic Method for the Synthesis of Cyclic Azaperoxides with High Cytotoxic Activity Full article

Journal

ChemistrySelect
ISSN: 2365-6549

Output data

Year: 2023, Volume: 8, Number: 37, Article number : e202302044, Pages count : DOI: 10.1002/slct.202302044

Authors

Makhmudiyarova Nataliya N. ¹ , Ishmukhametova Irina R. ¹ , Dzhemileva Lilya U. ² , D'yakonov Vladimir A. ² , Terent'ev Alexander O. ² , Dzhemilev Usein M. ²

Affiliations

1	Institute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences, 141 Prospekt Oktyabrya, Ufa, 450075 Russian Federation
2	N. D. Zelinsky Institute of Organic Chemistry, 47 Leninsky prospekt, Moscow, 119991 Russian Federation

An efficient method has been developed for the synthesis of N-aryl-1,2,4-dioxazolidines, N-aryl-tetraoxaspiroalkanes, and N-aryl-hexaoxadispiroalkanes by cycloaminomethylation of OH acids (hydrogen peroxide, gem-bis-hydroperoxides, and 1,1′-peroxybis(1-hydroperoxycycloalkanes)) with 1,3,5-triaryl-1,3,5-triazinanes in the presence of lanthanide catalysts. The eight-membered azadiperoxides were shown to exhibit a high cytotoxic activity against Jurkat, K562, and U937 tumor cells and Hek296 immortalized normal cells. The cytotoxic activity of Fe(II)-treated azadiperoxides against Jurkat tumor cells was studied; these compounds were shown to in Keywords: Catalysis; Cycloaminomethylation; Hydrogen peroxide; Gem-bis-hydroperoxides; 1,1′-Peroxy-bis(1-hydroperoxycycloalkanes); Azaperoxides; Cytotoxic activity initiate cell autophagy.

Makhmudiyarova N.N. , Ishmukhametova I.R. , Dzhemileva L.U. , D'yakonov V.A. , Terent'ev A.O. , Dzhemilev U.M.
A New Catalytic Method for the Synthesis of Cyclic Azaperoxides with High Cytotoxic Activity
ChemistrySelect. 2023. V.8. N37. e202302044 . DOI: 10.1002/slct.202302044 WOS Scopus OpenAlex

Web of science:	WOS:001077072300001
Scopus:	2-s2.0-85173789519
OpenAlex:	W4387267353

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