Regioselective synthesis of new imidazo[4,5‐e][1,3]thiazino[2,3‐c][1,2,4]triazines via reaction of imidazo[4,5‐e][1,2,4]triazinethiones with ethyl phenylpropiolate

Regioselective synthesis of new imidazo[4,5‐e][1,3]thiazino[2,3‐c][1,2,4]triazines via reaction of imidazo[4,5‐e][1,2,4]triazinethiones with ethyl phenylpropiolate Full article

Journal

Journal of Heterocyclic Chemistry
ISSN: 0022-152X , E-ISSN: 1943-5193

Output data

Year: 2024, Volume: 61, Number: 1, Pages: 137-145 Pages count : 9 DOI: 10.1002/jhet.4753

Authors

Vinogradov Dmitry B. ¹ , Izmest'ev Alexei N. ¹ , Kravchenko Angelina N. ¹ , Kolotyrkina Natalya G. ¹ , Gazieva Galina A. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

A method for the regioselective synthesis of imidazo[4,5-e][1,3]thiazino[2,3-c][1,2,4]triazine derivatives has been developed by the reaction of imidazotriazinethiones with ethyl phenylpropiolate upon treatment with potassium carbonate or sodium methoxide in methanol. The synthesis was accomplished by Michael-type addition of the imidazotriazinethiones to the triple bond of ethyl phenylpropiolate followed by subsequent intramolecular cyclization.

Vinogradov D.B. , Izmest'ev A.N. , Kravchenko A.N. , Kolotyrkina N.G. , Gazieva G.A.
Regioselective synthesis of new imidazo[4,5‐e][1,3]thiazino[2,3‐c][1,2,4]triazines via reaction of imidazo[4,5‐e][1,2,4]triazinethiones with ethyl phenylpropiolate
Journal of Heterocyclic Chemistry. 2024. V.61. N1. P.137-145. DOI: 10.1002/jhet.4753 WOS Scopus OpenAlex

Web of science:	WOS:001100100100001
Scopus:	2-s2.0-85176101733
OpenAlex:	W4388478818

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