Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones

Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones Full article

Journal

Molecules
ISSN: 1420-3049

Output data

Year: 2020, Volume: 25, Number: 23, Article number : 5748, Pages count : DOI: 10.3390/molecules25235748

Authors

Fadeev Alexander A. ^1,2 , Chagarovskiy Alexey O. ^3,4 , Makarov Anton S. ¹ , Levina Irina I. ⁵ , Ivanova Olga A. ^6,4 , Uchuskin Maxim G. ¹ , Trushkov Igor V. ^3,4

Affiliations

1	Department of Chemistry, Perm State University, Bukireva 15, Perm 614990, Russia
2	Department of Organic Chemistry, Faculty of Science, Charles University, Hlavova 8, 12800 Prague 2, Czech Republic
3	Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Samory Mashela 1, Moscow 117997, Russia
4	N. D. Zelinsky Institute of Organic Chemistry, Leninsky pr. 47, Moscow 119991, Russia
5	N. M. Emanuel Institute of Biochemical Physcis Russian Academy of Sciences, Kosygina 4, Moscow 117198, Russia
6	Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie gory 1-3, Moscow 119991, Russia

A simple general method for the synthesis of 1-acyl-2-(ortho-hydroxyaryl)cyclopropanes, which belong to the donor–acceptor cyclopropane family, has been developed. This method, based on the Corey–Chaykovsky cyclopropanation of 2-hydroxychalcones, allows for the preparation of a large diversity of hydroxy-substituted cyclopropanes, which can serve as promising building blocks for the synthesis of various bioactive compounds.

Fadeev A.A. , Chagarovskiy A.O. , Makarov A.S. , Levina I.I. , Ivanova O.A. , Uchuskin M.G. , Trushkov I.V.
Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones
Molecules. 2020. V.25. N23. 5748 . DOI: 10.3390/molecules25235748 WOS Scopus OpenAlex

Web of science:	WOS:000597905700001
Scopus:	2-s2.0-85097515070
OpenAlex:	W3111091092

DB	Citing
OpenAlex	5
Scopus	3
Web of science	4